Tauroursodeoxycholic acid (Ursodoxicoltaurine) 牛磺熊去氧胆酸；牛磺酸二醇

目录号 M5158 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

Tauroursodeoxycholic acid（Ursodoxicoltaurine）是乌索脱氧胆酸的牛磺酸共轭产物，同时也是一种内质网应激抑制剂。可显著降低凋亡分子如 caspase-3 和 caspase-12 表达。此外，Tauroursodeoxycholate 还能抑制 ERK。

别名：TUDCA; Ursodoxicoltaurine; Ursodeoxycholyltaurine; Tauroursodeoxycholate; UR 906; Taurursodiol

其他规格数量报价？

J Ethnopharmacol. 2022 October 5;296:115519.

Lycium barbarum L. and Salvia miltiorrhiza Bunge protect retinal pigment epithelial cells through endoplasmic reticulum stress
Biomed Pharmacother. 2018 Jul 20;106:1271-1281.

Tauroursodeoxycholic acid alleviates hepatic ischemia reperfusion injury by suppressing the function of Kupffer cells in mice.

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 7. TUDCA (AbMole BioScience Ltd.)
	方法	injected intraperitoneally
	细胞系/动物模型	mice
	浓度	400 mg/kg
	处理时间	3 d
	实验结果	Following treatment with TUDCA, the levels of all the proinflammatory cytokines were significantly decreased.

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 6. TUDCA (AbMole BioScience Ltd.)
	方法	injected intraperitoneally
	细胞系/动物模型	mice
	浓度	400 mg/kg
	处理时间	3 d
	实验结果	In contrast, following treatment with TUDCA, few TUNEL positive hepatic cells were observed compared with those in the I/R group

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 5. TUDCA (AbMole BioScience Ltd.)
	方法	injected intraperitoneally
	细胞系/动物模型	mice
	浓度	400 mg/kg
	处理时间	3 h, 6 h, and 24 h
	实验结果	However, following treatment with TUDCA, all the above mentioned markers were significantly decreased in the I/R + TUDCA group

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 4. TUDCA (AbMole BioScience Ltd.)
	方法	cell viability assay
	细胞系/动物模型	KCs
	浓度	25 μM
	处理时间	96 h
	实验结果	These results demonstrated that TUDCA effectively alleviates the apoptosis of AML cells.

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 3. TUDCA (AbMole BioScience Ltd.)
	方法	immunofluorescence staining
	细胞系/动物模型	KCs
	浓度	25 uM
	处理时间	24 h
	实验结果	The results of immunofluorescence staining showed that, following treatment with an increased concentration of TUDCA, the intensity of fluorescence in the nucleus of KCs was significantly decreased.

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 2. TUDCA (AbMole BioScience Ltd.)
	方法	RT-PCR
	细胞系/动物模型	KCs
	浓度	0 μM, 25 μM, 50 μM, and 100 μM
	处理时间	24 h
	实验结果	Moreover, following treatment with different concentrations of TUDCA, the level of the abovementioned proinflammatory cytokines presented a dose-dependent decrease

	数据来源	Biomedicine & Pharmacotherapy (2018). Figure 1. TUDCA (AbMole BioScience Ltd.)
	方法	cell viability assay
	细胞系/动物模型	KCs
	浓度	0 μM, 25 μM, 50 μM, and 100 μM
	处理时间	96 h
	实验结果	The effects of different concentrations of TUDCA on the cell viability of KCs were determined by the MTT assay

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.0012 mL	10.006 mL	20.012 mL
5 mM	0.4002 mL	2.0012 mL	4.0024 mL
10 mM	0.2001 mL	1.0006 mL	2.0012 mL

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

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