Recombinant Mouse S100A11 (E.coli , N-6His) 重组小鼠S100A11蛋白 (E.coli , N-6His)

目录号 M21525 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

重组小鼠蛋白S100-A11由大肠杆菌表达系统产生，目的基因Met1-Ile98在n端带有6His标记表达。蛋白编号：P50543。

Recombinant Mouse S100A11 (E.coli , N-6His)结构式

别名：Protein S100-A11; Calgizzarin; Endothelial monocyte-activating polypeptide

规格	价格	库存状态
10ug	¥ 1152	中国库存现货
50ug	¥ 2340	中国库存现货

其他规格数量报价？

质量标准及产品资料

纯度：＞95%, Endotoxin＜1 EU/µg
COA
MSDS

产品信息

生物活性

种属：Mouse

表达系统：E.coli

纯度：经还原SDS-PAGE测定，大于95%

分子量：12.6 KDa

内毒素：LAL测试测得小于0.1 ng/µg (1EU/µg)

存储及稳定性：冻干蛋白应保存在≤-20°C，接收后稳定保存一年。重组蛋白溶液可在2-8℃保存2-7天。重组样品的等分线在≤-20°C下稳定3个月

生物活性：蛋白质S100-A11(S100A11)是S-100家族的一员。S100A11广泛表达于多种组织中，分布于细胞质、细胞核甚至细胞外周。S100A11作为一种具有反平行构象的非共价同二聚体存在。Ca(2+)与S100A11结合会引起构象变化，从而暴露S100A11的疏水裂口，促进其与靶蛋白的相互作用。S100A11作为一种双细胞生长介质，在许多不同类型的肿瘤中既可作为肿瘤抑制因子，也可作为肿瘤启动因子，并在影响癌细胞增殖蛋白方面发挥各自的作用。在细胞核中，S100A11通过激活p21 (CIP1/WAF1)抑制角质形成细胞的生长，诱导细胞分化。S100A11也是一种新的乳腺癌诊断标志物。

化学性质

溶解性（25°C）	It is not recommended to reconstitute to a concentration less than 100μg/ml.
储存条件	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

参考文献

[1] Linqiang Zhang, et al. Cell Mol Gastroenterol Hepatol. S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis

[2] Qian Xia, et al. Cell Death Dis. S100A11 protects against neuronal cell apoptosis induced by cerebral ischemia via inhibiting the nuclear translocation of annexin A1

[3] Ashok R Amin, et al. DNA Cell Biol. Genomic analysis and differential expression of HMG and S100A family in human arthritis: upregulated expression of chemokines, IL-8 and nitric oxide by HMGB1

[4] Mayu Hanaue, et al. Mol Reprod Dev. Characterization of S100A11, a suppressive factor of fertilization, in the mouse female reproductive tract

[5] Denise L Cecil, et al. J Immunol. Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes

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Recombinant Mouse S100A11 (E.coli , N-6His) 重组小鼠S100A11蛋白 (E.coli , N-6His)

目录号 M21525 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

质量标准及产品资料

生物活性

化学性质

参考文献

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