Pregnane X Receptor 激动剂/激活剂 Pregnane X Receptor (PXR)
| 目录号 | 产品名称 | 产品简介 |
|---|---|---|
M21085
|
Pregnenolone 16α-carbonitrile | Pregnenolone 16α-carbonitrile是孕烯二酮的一种衍生物，作为强效鼠特异性孕烷X受体（PXR）的激动剂发挥作用。Pregnenolone 16α-carbonitrile 是一种合成类固醇，可诱导细胞色素 P450 3A 的表达。Pregnenolone 16α-carbonitrile 对随后的应激性损伤表现出更强的耐受性。 |
| M7324
|
SR 12813 | SR 12813 is an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR). SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM. |
