M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M20900
|
Saccharin |
Saccharin is an artificial sweetener with effectively no food energy. |
| M20899
|
Diatrizoate sodium |
Diatrizoate sodium is an iodinated radiopaque X-ray contrast medium that is used as a diagnostic aid in angiography, urography and radiography. |
| M20897
|
Sodium benzoate |
Sodium benzoate is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions. |
| M20896
|
Iron sucrose |
Iron sucrose is an intravenously administered iron product indicated in the treatment of iron deficiency anemia. |
| M20881
|
2-cyano-Pyrimidine |
2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM. |
| M20876
|
Dihydrocholesterol |
Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. |
| M20871
|
Piperazine adipate |
Piperazine adipate is a broad spectrum anthelmintic agent that inhibits malate oxidation in Ascaridia galli and Heterakis gallinae. |
| M20870
|
Sodium phenylpyruvate |
Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption. |
| M20867
|
Potassium sorbate |
Potassium sorbate (Sorbic acid potassium) is a nonpoisonous food preservative isolated from Sorbus aucuparia. Potassium sorbate is an effective inhibitor of most molds and yeasts and some bacteria. |
| M20862
|
BCH |
BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells. |
| M20860
|
Eptifibatide Acetate |
Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes. |
| M20857
|
Ethyl potassium malonate |
Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate. |
| M20856
|
H-HoArg-OH |
H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases. |
| M20849
|
(Ala13)-Apelin-13 |
(Ala13)-Apelin-13 is a potent APJ receptor antagonist and can prevent the apelin-induced reduction in gastric tone and motility. |
| M20840
|
INH154 |
INH154 is a potent inhibitor of Nek2 and Hec1 binding. NH154 binds to Hec1, thus blocking Hec1 phosphorylation by NEK2, and kills cancer cells at the nanomolar range. |
| M20838
|
Fluorofenidone |
Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway. |
| M20834
|
Pizuglanstat (TAS-205) |
Pizuglanstat (TAS-205) is a highly selective hematopoietic prostaglandin D synthase (HPGDS) inhibitor with an IC50 of 55.8 nM. |
| M20818
|
HOIPIN-1 |
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM for inhibiting the in vitro linear ubiquitination activity of the petit-LUBAC. |
| M20817
|
ML198 |
ML198 is a novel activator of glucocerebrosidase (GCase) and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome. |
| M20812
|
KUN50259 (DAAO inhibitor-1) |
KUN50259 (DAAO inhibitor-1, Compound 35) is a potent inhibitor of D-amino acid oxidase (DAAO) with an IC50 of 0.12 μM. |
