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Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe is a synthetic thrombin receptor agonist peptide.
别名：TRAP; ThroMbin Receptor Agonist Peptide
Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe is a synthetic thrombin receptor agonist peptide. SFLLRNPNDKYEPF activates and induces platelet aggregation and serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。
| 分子量 | 1739.92 |
| 分子式 | C81H118N20O23 |
| CAS号 | 137339-65-2 |
| 纯度 | >97% |
| 溶解性（25°C） | Water 40 mg/mL DMSO 70 mg/mL |
| 储存和运输条件 |
-20°C, dry, sealed
常温运输及临时存放 |
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.5747 mL | 2.8737 mL | 5.7474 mL |
| 5 mM | 0.1149 mL | 0.5747 mL | 1.1495 mL |
| 10 mM | 0.0575 mL | 0.2874 mL | 0.5747 mL |
Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells
Y Maruyama, et al. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9. PMID: 8147869.
Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism
Y Sugama, et al. Circ Res. 1992 Oct;71(4):1015-9. PMID: 1381292.
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