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Recombinant Rat Insulin-like Growth Factor-1 (E. coli) 重组大鼠胰岛素样生长因子-1(IGF-1)(E. coli)

目录号 M10460 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组大鼠胰岛素样生长因子-1(IGF-1)(E. coli)属于胰岛素基因家族,是促有丝分裂多肽生长因子,可在体外刺激包括肌肉、骨骼和软骨组织在内的各种细胞类型的增殖和存活。

Recombinant Rat Insulin-like Growth Factor-1 (E. coli)结构式

别名:rRtIGF-1

规格 价格 库存状态
10ug ¥ 980 中国库存现货
50ug ¥ 1400 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
生物活性

重组大鼠胰岛素样生长因子-1(IGF-1)属于胰岛素基因家族,是促有丝分裂多肽生长因子,可在体外刺激包括肌肉、骨骼和软骨组织在内的各种细胞类型的增殖和存活。IGF 在结构和功能上与胰岛素相似,但具有比胰岛素高得多的促生长活性。IGF-1 主要由肝脏作为内分泌激素以及以旁分泌/自分泌方式在靶组织中产生。IGF-1 的产生受到生长激素 (GH) 的刺激,可因营养不良、生长激素不敏感、缺乏生长激素受体或 GH 受体(包括 SHP2 和 STAT5B)后下游信号通路的故障而受阻。

通过使用 FDCP-1 细胞的细胞增殖试验测定的 ED50小于 10 ng/mL,对应于 > 1×105 units/mg 的比活性。

序列: MGPETLCGAE LVDALQFVCG PRGFYFNKPT GYGSSIRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPTKS A

化学性质
溶解性(25°C) Reconstituted in ddH2O at 100 μg/mL
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] R G Thorne, et al. Neuroscience. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

[2] E Schoenle, et al. Nature. Insulin-like growth factor I stimulates growth in hypophysectomized rats

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