重组人TGF-β1（Recombinant Human TGF-β1）是一种多功能细胞因子，调节细胞增殖、生长、分化和运动，以及细胞外基质的合成和沉积。通过抑制 IL-4 依赖性的小鼠 HT-2 细胞的增殖能力来测定的ED50值为 ≤0.5 ng/mL。
别名：TGF-beta1
重组人转化生长因子-β1（Recombinant Human TGF-β1）是几乎所有细胞类型分泌的最丰富的异构体。它最初被认为具有诱导成纤维细胞表型转化的能力。转化生长因子-β、转化生长因子-β1、β2 和β3 三种哺乳动物亚型通过同一受体发出信号，引起相似的生物学反应。它们参与各种生理过程，包括胚胎发生、组织重塑和伤口愈合。它们主要以潜在复合物的形式分泌，储存在细胞表面和细胞外基质中。从潜在复合物中释放生物活性的转化生长因子-β异构体，包括蛋白水解、复合物的加工和/或凝血酶反应素-1 等蛋白质的构象变化。
以抑制小鼠IL-4依赖性的小鼠HT-2细胞的增殖能力来测定，其ED50值为 ≤0.5 ng/mL。
DNA 序列编码人 TGF-β1（NP_000651.3）表达带有 Fc 标签在 C 末端。
重组人 TGF-β1 蛋白包含 374 个氨基酸，预测的理论分子量为 42.2kD。
内毒素：<0.1EU/μg
Allergol Immunopathol (Madr). 2022 Mar 1;50(2):104-114.
6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1
 |
数据来源 | Recombinant Human TGF-β1 (AbMole) |
| 方法 | SDS-PAGE analyses | |
| 细胞系/动物模型 | ||
| 浓度 | ||
| 处理时间 | ||
| 实验结果 | The purity is > 97 % by SDS-PAGE analyses. |
| 溶解性（25°C） | Reconstitute the lyophilized powder in ddH2O or PBS up to 50 μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
| 其他相关的Recombinant Proteins产品 |
|---|
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli, aa 18-169, His Tag)
The recombinant human IL1F9 consists of 168 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL1F9 (Ser18-Asp169) was expressed with a polyhistide tag at the N-terminus. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli)
The recombinant human IL1F9 consisting of 169 amino acids and has a calculated molecular mass of 18.9 kDa. A DNA sequence encoding the human IL-1F9 isoform 1 (Met 1-Asp 169) was expressed. |
| Recombinant Human APOL1 Protein (Baculovirus-Insect, C-His)
APOL1, also known as apolipoprotein L1, belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. |
| Recombinant Human KGF/FGF-7 Protein (E. coli, His Tag)
KGF/Fibroblast growth factor 7 (FGF7) plays an important role in regulating the proliferation, migration, and differentiation of cells. FGF7 is of stromal origin and produces a paracrine effect on epithelial cells. |
| Recombinant Dengue virus (DENV) (type 2, strain New Guinea C) NS1 Protein (HEK293, N-His)
The Recombinant Dengue virus (type 2, strain New Guinea C) NS1 consists of 371 amino acids and predicts a molecular mass of 42.3 kDa. A DNA sequence encoding the Dengue virus (type 2, strain New Guinea C) NS1 (Asp1-Ala352) was expressed with a polyhistidine tag at the N-terminus. |
产品仅供科学研究或药证申报的用途使用，不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号
蛋白质研究