重组人RANKL是肿瘤坏死因子(TNF)超家族的II型膜蛋白，影响免疫系统，控制骨再生和重塑。RANKL为核因子(NF)-κB (RANK)配体。
别名：CD254
重组人RANKL是肿瘤坏死因子(TNF)超家族的II型膜蛋白，影响免疫系统，控制骨再生和重塑。RANKL为核因子(NF)-κB (RANK)配体。当RANKL与RANK结合时，会发生三聚体化，然后与接头分子TNF受体相关因子6 (TRAF6)结合。这导致多个下游信号级联的激活，包括nf - κ b、丝裂原活化蛋白激酶(MAPK)、活化蛋白1 (AP-1)和活化T细胞核因子(NFATc1)，导致多核骨吸收破骨细胞的形成。RANKL广泛表达于骨骼肌、胸腺、肝脏、结肠、小肠、肾上腺、成骨细胞、乳腺上皮细胞、前列腺、胰腺等。
2μg/ml (100 μl/孔)固定化RANKL可与Human OPG-His结合。
RANKL的ED50为0.15 ug/ml。
| 溶解性（25°C） | Reconstituted in ddH2O or PBS at 100 μg/mL |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
[4] I Silva, et al. Acta Reumatol Port. Rank/Rankl/opg: literature review
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