重组人白介素4(Recombinant Human IL-4)在由单核细胞诱导成DC的过程中抑制巨噬细胞的过度生长,从而引导单核细胞向DC方向分化。
重组人白介素4(Recombinant Human IL-4)在由单核细胞诱导成DC的过程中抑制巨噬细胞的过度生长,从而引导单核细胞向DC方向分化。同时,IL-4还有降低细胞表面表达CD14分子的能力。CD14表达水平的降低是单核细胞分化为DC的重要标志。GM-CSF和IL-4共同作用可使单核细胞定向分化为未成熟DC(immature DC),此时的DC具有较强的抗原摄取和加工能力,但抗原递呈能力很弱。
DNA 序列编码人 IL-4(GenBank: AAH70123.1 H25-S153)表达带有 Fc 标签在 C 末端。
通过用 TF-1 细胞进行细胞增殖测定,测得的ED50为≤0.5 ng/mL。
内毒素 <0.1 EU/μg
性状 | Lyophilized powder |
溶解性(25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
储存条件 | Stored at ≤-20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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