重组人HGFR蛋白（Recombinant Human HGFR Protein）是一种糖基化受体酪氨酸激酶，在上皮形态发生和癌症发展中起着核心作用。
重组人HGFR蛋白（Recombinant Human HGFR Protein）是一种糖基化受体酪氨酸激酶，在上皮形态发生和癌症发展中起着核心作用。HGFR蛋白具有酪氨酸激酶活性。原发性单链前体蛋白经翻译后剪切产生α亚单位和β亚单位，二硫化物连接形成成熟受体。HGFR通常由上皮细胞表达，HGF的表达仅限于间充质细胞。在HGF刺激下，HGFR诱导几种生物反应，共同产生一种称为侵袭性生长的程序。癌症中异常的HGFR激活与预后不良相关，异常活跃的HGFR会触发肿瘤生长，形成新的血管（血管生成），为肿瘤提供营养，并且癌症会扩散到其他器官（转移）。在许多类型的人类恶性肿瘤中，包括肾癌、肝癌、胃癌、乳腺癌和脑癌，HGFR被解除管制。HGFR介导一个复杂的程序，称为侵入性生长。HGFR的激活触发有丝分裂和形态发生。固定化人肝细胞生长因子10μg/ml（100μl/孔）可与人肝细胞生长因子R（His标签）结合线性范围为2-100 ng/ml。
内毒素（Endotoxin）
＜0.1EU/ug
表达宿主（Expression host）
人HEK293细胞
| 溶解性（25°C） | Water Saline PBS |
| 储存条件 | 2-8°C, dry, sealed |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
| 其他相关的Recombinant Proteins产品 |
|---|
| Recombinant Mouse E-Selectin/CD62E Protein (HEK293)
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. |
| Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
| Recombinant Human USP14 (E.coli, N-6His)
USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. |
| Recombinant Human EpCAM/Trop-1 (Mammalian, C-Fc)
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein. EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli, aa 18-169, His Tag)
The recombinant human IL1F9 consists of 168 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL1F9 (Ser18-Asp169) was expressed with a polyhistide tag at the N-terminus. |
产品仅供科学研究或药证申报的用途使用，不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号
蛋白质研究