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Recombinant Human 4-1BB Protein (HEK293) 重组人4-1BB蛋白 (HEK293)

目录号 M11390 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Recombinant Human 4-1BB Protein (HEK293) 蛋白序列:DNA 序列编码人 4-1BB( UniProtKB/Swiss-Prot: Q07011.1)表达带有 His 标签在 C 末端 生物活性:4-1BB 又称 CD137,是由淋巴细胞活化(ILA)诱导的肿瘤坏死因子受体超家族成员 9(TNFRSF9),是肿瘤坏死因子(TNF)受体超家族的共刺激分子。

Recombinant Human 4-1BB Protein (HEK293)结构式

别名:TNFRSF9、4-1BB、CD137、CDw137、ILA

规格 价格 库存状态
10ug ¥ 1350 中国库存现货
20ug ¥ 2250 中国库存现货
50ug ¥ 3150 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95% , Endotoxin <0.1EU/μg
  • COA
  • MSDS
生物活性

表达宿主:人 HEK293 细胞

来源:Human

分子量:Human 4-1BB Protein 包含 162 个氨基酸,预测理论分子量为 19 kd

纯度:≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内毒素:<0.1EU/μg

存储及稳定性:冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融


生物活性:固定人 4- 1BB 的配体(FC 标签)的浓度为 1ug/mL(100uL/孔)能够够结合人 4-1BB(his 标签)的线性范围为 0.2-10 ng/mL

化学性质
溶解性(25°C) N/A
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Shannon K Oda, et al. J Exp Med. A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy

[2] Angela C Boroughs, et al. Mol Ther. A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

[3] Marta Trb, et al. J Immunother Cancer. Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer

[4] Nathalie Bonnefoy, et al. Med Sci (Paris). [Next generation of anti-immune checkpoints antibodies]

[5] Omkar U Kawalekar, et al. Immunity. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

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