白细胞介素-33 (IL-33) 是一种促炎细胞因子，属于 IL-1 家族。IL-33 在多种细胞中表达，包括上皮细胞和内皮细胞、平滑肌细胞、巨噬细胞和成纤维细胞。IL-33 的主要受体是 ST2 和 IL-1 受体辅助蛋白 (IL-1RAcP)，IL-33 在损伤过程中由细胞分泌，诱导 T 辅助 2 型炎症反应。
别名：rHuIL-33; IL-1F11
Human Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 plays a role in autoimmune disease. IL-33’s interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response.
ED50 < 0.5 ng/ml, measured by a cell proliferation assay using D10S cells, corresponding to a specific activity of > 2.0 × 106 units/mg.
| 溶解性（25°C） | Reconstitute in ddH₂O up to 100 μg/ml |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究