促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子,主要以其在促红细胞生成中的作用而闻名,它负责刺激红系祖细胞的增殖和分化。
别名:Erythropoietin
促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子,它负责刺激红系祖细胞的增殖和分化。只有在EPO存在的情况下,CFU-E细胞才能分化为红细胞。成年哺乳动物体内EPO的生理水平主要由肾脏维持,而胎儿或新生哺乳动物的EPO水平则由肝脏维持。EPO还能发挥多种非造血活性,包括血管化和平滑肌增殖,缺氧时的神经保护等。
DNA序列编码人EPO(NP_000790.2)表达带有His标签在C末端。
重组人EPO蛋白包含172个氨基酸,预测分子量为19.2kD。
通过用TF-1细胞进行细胞增殖测定,测得的ED50值为≤5 ng/mL。
内毒素< 0.1EU/μg
Nucleic Acids Res. 2022 Aug 12;50(14):7938-7958.
溶解性(25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
储存条件 | Stored at -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
其他相关的Recombinant Proteins产品 |
---|
Recombinant Human IL-10 (CHO)
Interleukin-10 (IL-10) is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. |
Recombinant Human IL-5 (CHO)
Interleukin-5 (IL-5) is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF). IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. |
Recombinant Human Tau-F Protein (E.coli)
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. |
Recombinant Human Tau Protein (E. coli, His Tag)
Tau proteins are proteins that stabilize microtubules. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. |
Recombinant Rat IL-23 Protein (HEK293, C-His)
IL-23 (IL-23 alpha & IL-12 beta Heterodimer) Protein is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293. |
产品仅供科学研究或药证申报的用途使用,不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号