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Recombinant Human EPO Protein (HEK293, C-His) 重组人EPO蛋白 (HEK293, C-His)

目录号 M9241 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子,主要以其在促红细胞生成中的作用而闻名,它负责刺激红系祖细胞的增殖和分化。

Recombinant Human EPO Protein (HEK293, C-His)结构式

别名:Erythropoietin

规格 价格 库存状态
50ug ¥ 3510 中国库存现货
100ug ¥ 5985 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >90%, Endotoxin <0.1EU/ug
  • COA
  • MSDS
生物活性

促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子,它负责刺激红系祖细胞的增殖和分化。只有在EPO存在的情况下,CFU-E细胞才能分化为红细胞。成年哺乳动物体内EPO的生理水平主要由肾脏维持,而胎儿或新生哺乳动物的EPO水平则由肝脏维持。EPO还能发挥多种非造血活性,包括血管化和平滑肌增殖,缺氧时的神经保护等。

DNA序列编码人EPO(NP_000790.2)表达带有His标签在C末端。

重组人EPO蛋白包含172个氨基酸,预测分子量为19.2kD。

通过用TF-1细胞进行细胞增殖测定,测得的ED50值为≤5 ng/mL。


内毒素< 0.1EU/μg

使用AbMole产品发表的文献
化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
储存条件 Stored at -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Middleton SA, et al. J Biol Chem. Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.

[2] Livnah O, et al. Nat Struct Biol. An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.

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