Ammonium Glycyrrhizinate是来自甘草的特有产物,具有极高的甜味。Ammonium Glycyrrhizinate 是 HMGB1 的直接抑制剂,Ammonium Glycyrrhizinate 通过抑制HMGB1的水平,可以显著降低自噬的有效生物标志物LC3和Beclin-1蛋白的表达。Ammonium Glycyrrhizinate 具有抗炎、抗肿瘤、抗糖尿病的作用。
别名:AMGZ, Glycyram
Mono-ammonium glycyrrhizinate (AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. It is an excellent foaming agent that acts as a co-emulsifier. It is also excellent in recipes that require gelling or suspension properties for a consistent feeling in the mouth or a stable cloud effect in the product.Very small quantities are required to achieve the desired results, usually a few parts per million. However, varying amounts should be evaluated in your product for best taste.MAGZ is up to 50 times sweeter than sucrose — and can greatly enhance an already sweetened product as a result of synergies with both natural and synthetic sweeteners. It was found to be active against viruses, while not affecting cell activity and ability to replicate. It was also reported that glycyrrhizic acid inactivates herpes simplex particles irreversibly.
分子量 | 839.96 |
分子式 | C42H62O16.NH3 |
CAS号 | 1407-03-0 |
溶解性(25°C) | DMSO 100 mg/mL Water 5 mg/mL |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前,需考虑其在不同溶剂中的溶解度限制。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.1905 mL | 5.9527 mL | 11.9053 mL |
5 mM | 0.2381 mL | 1.1905 mL | 2.3811 mL |
10 mM | 0.1191 mL | 0.5953 mL | 1.1905 mL |
小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
动物 A的Km系数 |
例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。
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