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Pim

抑制剂

目录号 产品名称 产品简介
M9676 TP-3654 TP-3654是新一代的Pim激酶抑制剂,它对Pim-1和Pim-3的Ki值分别为5和42 nM。
M9274 SMI-16a SMI-16a 是Pim-1/2激酶的有效的,细胞渗透性的,ATP竞争性抑制剂,对Pim1和Pim2的IC50值分别为150和20 nM。
M5321 CX-6258 HCl CX-6258 HCl 是强效的可口服的pan-Pim kinase抑制剂,其对Pim1, Pim2, 和 Pim3的IC50分别为5 nM, 25 nM 和 16 nM。
M5019 TCS-PIM-1-4a TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK; kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM).
M4810 AZD-1208 AZD1208 is a potent, highly selective, and orally available Pim kinase inhibitor that effectively inhibits all three isoforms at <5 nM or <150 nM in enzyme and cell assays, respectively.
M3745 TCS PIM-1 1 TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s > 20,000 nM).
M3146 CX-6258 CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.
M2572 SMI-4a SMI-4a是一种有效的Pim1抑制剂,IC50为17 nM,作用于Pim-2适度有效,抑制其他丝/苏氨酸或酪氨酸激酶作用不显著。
M1779 SGI-1776 SGI-1776 free base是一种新型的,ATP竞争性的Pim1抑制剂,IC50为7 nM,比作用于Pim2和Pim3选择性分别高50和10倍,作用于Flt3和haspin也有效。
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