Immunology/Inflammation 抑制剂/激活剂/调节剂 Immunology/Inflammation

目录号	产品名称	产品简介
M25413	Fucoxanthin	岩藻黄质 Fucoxanthin 是一种天然存在于某些藻类中的类胡萝卜素，具有抗肥胖、抗氧化、抗糖尿病、抗癌和抗炎活性。
M20413	4-Biphenylacetic acid	4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
M10093	α-Galactosyl Ceramide	α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) α-半乳糖神经酰胺是一种强大的NKT细胞刺激剂，和选择性CD1d配体。α-Galactosylceramide (α-GalCer) 是一种合成的糖脂，具有抗肿瘤和免疫刺激作用。
M9358	ITE	ITE是一种有效的，内源性的芳烃受体（AhR）的激动剂，可直接与AhR结合，Ki为3 nM。
M4614	Orientin	Orientin（荭草苷）是一种可从药用植物中分离的生物活性化合物，能有效地抑制Sortase A的活性，其IC50为50.44 ± 0.51 µM。还可以通过Nrf2以及JNK/cytochrome c/caspase-3信号通路，抑制APAP诱导的肝细胞氧化损伤和线粒体功能障碍，具有抗氧化，抗炎和抗癌活性。
M1831	Cyclosporine A	Cyclosporin A（环胞菌素，环孢菌素，环胞霉素A，环孢素A，环蒽孢A，环孢素）是一种由11个氨基酸组成的环状非核糖体肽，同时也是一种大环类化合物，可与亲环蛋白18(Cyp18)结合，抑制钙调神经磷酸酶(CaN)的活性，IC50值为7 nM。此外，Cyclosporin A还能抑制T细胞活化，具有免疫抑制活性，可用于干眼症、类风湿性关节炎和银屑病的相关研究。
M54780	Naringenin	Naringenin 是柑橘/葡萄柚中主要的黄烷酮，显示出强烈的抗炎和抗氧化活性。Naringenin 具有抗登革热病毒 (DENV) 活性。
M40934	Anti-Mouse CTLA-4 (Clone 9D9) In vivo	Anti-Mouse CTLA-4 Antibody (Clone 9D9) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes.
M40918	Anti-Mouse Ly6G (Clone 1A8) In vivo	Anti-Mouse Ly6G antibody (Clone 1A8) In vivo recognizes an epitope on mouse Ly6G. Ly6G is expressed by neutrophils.
M40909	Anti-Mouse CD8a (Clone 53-6.7) In vivo	Anti-Mouse CD8a (Clone 53-6.7) In vivo recognizes Lyt 2. Clone 53-6.7 competes with clone 5H10-1 for binding to thymocytes.
M40830	Anti-Mouse CD3ε In vivo	Anti-Mouse CD3ε (Clone 145-2C11) In vivo单克隆抗体与小鼠CD3ε反应。小鼠CD3ε是一种20 kDa的跨膜细胞表面蛋白，属于免疫球蛋白超家族。
M40828	Anti-Mouse CTLA-4 (Clone 9H10) In vivo	Anti-Mouse CTLA-4 (Clone 9H10) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes.
M40812	Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo	Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo has been used to identify peripheral blood neutrophils and deplete granulocytes in vivo.
M21680	TJ-M2010-5	TJ-M2010-5 是一种 MyD88 抑制剂，可与 MyD88 的 TIR 结构域结合以干扰其同源二聚化和 TLR/MyD88 信号通路。
M20985	Perflubron	Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties.
M20958	Talniflumate	Talniflumate是niflumic acid的前药，也是一种新型的，选择性的核心粘蛋白合成酶（GCNT3）抑制剂，同时具有抗炎和止痛活性，可用于囊性纤维化、慢性阻塞性肺病（COPD）和类风湿性关节炎等的相关研究。
M20433	Tolmetin	Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
M20432	5-Acetylsalicylic acid	5-Acetylsalicylic acid is an aminosalicylate anti-inflammatory agent, which has anti-inflammatory and is considered to be the active agent in inflammatory bowel disease (IBD).
M20412	NLRP3 Inflammasome Inhibitor I	NLRP3 Inflammasome Inhibitor I是一种新型的 NLRP3 炎症小体抑制剂，同时也是格列苯脲合成过程中的中间底物，不含参与胰岛素释放的环己基脲分子。
M18258	11beta,13-Dihydrolactucin	11beta,13-Dihydrolactucin 11b,13-二氢山莴苣素是一种倍半萜内酯，通过乳糖苷的 11,13-双键正式氢化而获得。它是一种植物代谢物。

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Immunology/Inflammation 抑制剂/激活剂/调节剂 Immunology/Inflammation

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